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Air Freshener Induced Oxidative Stress and Its Adverse Effects on Immunity 1*Augustine I. Airaodion, 2Dolapo S. Olawoyin, 2Oladeji J. Alabi, 2Festus Atiba, and Emmanuel O. Ogbuagu3 1Department of Biochemistry, Federal University of Technology, Owerri, Imo State, Nigeria. 2Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. 3Department of Pharmacology and Theraupetics, Abia State University, Uturu, Nigeria. *Corresponding Author’s Contact Details: E-mail Addresses ✉: bayode.augustineairaodion@yahoo.com; Phone no ☎: +(234)7030204212 Accepted June 23, 2020 Recently, the use of ‘sunlight’ air freshener in Nigeria is on the increase. Some people use air freshener in the office, car as well as in their homes, thereby constantly being exposed to it without consideration of its adverse effect on human health. This study is therefore aimed at assessing the effect of “sunlight” air freshener on oxidative stress biomarkers. Thirty (30) Wistar rats were divided into three groups of ten each and kept in different rooms. Rats in group 1 were not exposed to any substance; those in groups 2 and 3 were exposed to sunlight air freshener for 8 hours daily for 28 days by inhalation. After 28 days exposure, animals in group 3 were allowed to recover for 14 days. Throughout the experiment, all animals were fed ad libitum with standard feed and drinking water. At the end of the experiment, rats were sacrificed after an overnight fast under diethyl ether as anesthesia. Blood samples were collected through cardiac puncture. Oxidative stress biomarkers were determined using standard methods. The result showed that air freshener significantly increased lipid peroxidation but significantly reduced glutathione concentration after 28 days of exposure. Activities of antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) were observed to significantly increase due to air freshener exposure when compared with those in the control group. The effects of air freshener on oxidative stress biomarkers (except glutathione) were reversed when animals exposed to air freshener for 28 days were allowed to recover for 14 days. This study revealed that sunlight air freshener induced oxidative stress, thus possesses the propensity to destroy the immune system. Frequent use of this air freshener should be discouraged. Key words: Air Freshener, Antioxidants, Free Radicals, Immunity, Oxidative Stress. Full Text PDF (555 KB) |
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