ANTIOXIDANT AND ANTIDIABETIC PROPERTIES OF ELEUCINE CORACANA (L.) GEARTN. (FINGER MILLET)SEED COAT MATTER IN STREPTOZOTOCIN INDUCED DIABETIC RATS

¹Okoyomoh K., ²Okere O.S., ³Olowoniyi O.D. and ^2*Adejo G.O.

¹Department of Biochemistry, Faculty of Science, Ahmadu Bello University, Zaria, Nigeria.
²Department of Biochemistry, Faculty of Science and Technology, Bingham University, Nasarawa State, Nigeria.
³Department of Science Laboratory Technology, School of Applied Science, Nasarawa Federal Polytechnic, Nasarawa State, Nigeria.

Accepted November 28, 2013

Herbal drugs are traditionally used in various parts of the world to cure different diseases. The present study evaluates the antioxidant and antidiabetic properties of seed coat matter (SCM) of grains of black finger millet (Eleusine coracana (L.) Geartn.). 20% and 40% in streptozotocin (STZ) induced diabetic rats. Eleusine coracana exhibited significant antidiabetic activity resulting to a 45% reduction in the diabetic experimental group treated with 40%SCM. Feeding the experimental rats with various concentration of the SCM exhibited significant protective effect by lowering the serum levels of alanine transaminase(ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP). Catalase (CAT) and superoxide dismutase (SOD) activities were increased while the concentration of thiobarbituric acid reactive substances (TBARS) was significantly lowered. Histo-pathological observations also revealed that SCM of Eleusine coracana offered protection to the animals against pancreatic, kidney and liver STZ induced damages. The result indicates that the various concentrations of Eleusine coracana grains possess antioxidant and antidiabetic potentials in STZ induced diabetic rats.

Key words: Finger millet, Hyperglycaemia, Seed coat matter, Streptozotocin.

Abbrevations: AGE, advanced glycation end product; DC, diabetic control; DE, diabetic experimental; NC, normal control; SCM, seed coat matter; STD DRG, standard drug.

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